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Effects of podocin transfection on CD2AP distribution in HEK293 cells

SHA Yugen, HUANG Songming, ZHANG Aihua, ZHAO Fei, CHEN Ronghua

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 35-38 doi: 10.1007/s11684-008-0007-0

Abstract: The aim of this paper is to construct a podocin fluorescence expression vector and observe the effectsof podocin transfection on CD2AP distribution in HEK293 cells.The digested full-length podocin was subcloned into pEGFP-C2.The constructed plasmids were transfected into HEK293 cells and its effects on CD2AP distribution wereThe pEGFP-NPHS2 expression vector was successfully constructed and podocin exclusively located on the

Keywords： pEGFP-NPHS2 expression     transfection     pEGFP-C2     cytoplasm     digested    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: This study aims to demonstrate that blocking the receptor-interacting protein2 (Rip2) expression canRip2 expression was detected with reverse transcription-polymerase chain reaction (RT-PCR) and westernRip2 siRNA plasmid could block the mRNA and protein expression of Rip2 and promote cell proliferationThe HMGB1 expression in the liver decreased to (40.21 ± 11.03) pg/g, and serum TNF-?The results demonstrate that Rip2 siRNA plasmid can block the expression of Rip2, decrease the production
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Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium

Yan Chen,Wenyan Li,Wen Li,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 330-335 doi: 10.1007/s11684-016-0459-6

Abstract: However, the detailed expression profile of Ezh2 during mouse cochlear development has not been investigatedHere, we examined the spatiotemporal expression of Ezh2 in the cochlea during embryonic and postnatalEzh2 expression began to be observed in the whole otocyst nuclei at embryonic day 9.5 (E9.5).At postnatal day (P) 0 and 7, the Ezh2 expression was located in the nuclei of the cochlear epitheliumOur results provide the basic Ezh2 expression pattern and might be useful for further investigating the

Keywords： polycomb repressive complex     Ezh2     expression     inner ear     cochlea     development    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: (PP2A) activity, and on tau phosphorylation.Specific Src siRNA was transfected into cultured mouse neuroblastoma N2a cells to inhibit the expressionof Src protein, and the phosphorylation levels of PP2A Y307 and tau at different sites, as well as PP2AHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.Inhibiting Src expression could induce inactivation of PP2A and tau hyperphosphorylation.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: Further, Pearson’s correlation coefficient revealed a positive correlation between GTF2I expression andFAT1 expression.The under-expression of GTF2I and FAT1 was validated in TC cell lines.its expression.stemness maintenance by increasing the expression of FAT1 and facilitating the FAT1-mediated CDK4/FOXM1

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

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Effect of pEGFP-survivin on GBC-SD cell growth and chemotherapy sensitivity

Hanbin SHEN MD, Bin ZHANG MBA, Song ZHAO BM, Qichang ZHENG MD, Jianping GONG MD, Xiaotang CAI BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 485-490 doi: 10.1007/s11684-009-0089-3

Abstract: green fluorescent protein (EGFP), and GBC-SD/survivin cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and mRNA and protein of survivin were tested by reverseCell viability was decreased significantly in GBC-SD/survivin cells, and survivin expression was decreasedThe survivin shRNA could down-regulate the expression of survivin in GBC-SD cells significantly and improve

Keywords： survivin     shRNA     chemotherapy     sensibility     GBC-SD    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-2 mRNA expression in the liver and small intestine of allogeneic HSCT mice (in liver: 0.010±mRNA expression in the other organs (>0.05) was not found to be significantly elevated.PAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.Our findings of markedly increased expression of PAR-1, 2 in target organs of acute GVHD suggest that

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 130-136 doi: 10.15302/J-FASE-2014013

Abstract: In this study, using real-time quantitative RT-PCR, we investigated the expression pattern of and itsSmall white follicles were found to have significantly higher expression of and mRNA than any otherThe expression of and mRNA were detected in both granulosa and theca layers of pre-ovulatory follicles, the expression of in theca layers was slightly higher than in granulosa cells.These results indicate that the head-to-head genes of and exhibit similar expression in chicken follicles

Keywords： chicken     Vps36     Ckap2     mRNA     follicle    

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Identification of genome regions and important variations associated with expression level of

Ye HOU,Lu JING,Yunxia ZHAO,Sheng WANG,An LIU,Shuhong ZHAO,Xinyun LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 237-241 doi: 10.15302/J-FASE-2015057

Abstract: muscle fibers contain three isoforms, IIa, IIb and IIx, which contain specific myofibrillar proteins MYH2,In this study, the expression levels of , , and genes in the Longissimus thoracis (LT) muscle wereThe results showed that the expression level of was positively correlated with the intramuscular fatThe expression levels of and were negatively correlated with the pH at 24 h post mortem (pH ; =The results indicated the expression levels of , and genes could be useful markers for improvement

Keywords： pig     IMF     pH     MYH1     MYH2     MYH4    

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Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different

Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han

Frontiers of Medicine   Pages 185-192 doi: 10.1007/s11684-020-0754-0

Abstract: originated from Wuhan (China), invades human cells via the receptor angiotensin converting enzyme II (ACE2)Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infectionesophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2)

Keywords： 2019-nCoV     ACE2     single-cell RNA-seq    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: The ablation of gene decreased the expression levels of thyroid hormone-inducible nuclear protein 14(Spot14) and cytochrome P450 (Cyp2e1) in the liver, especially after CCl treatment for 48 h.These data suggested that the alleviated liver damage induced by CCl in mice was caused by Cyp2e1

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 99-103 doi: 10.1007/s11684-007-0019-1

Abstract: We detected loss of heterozygosity (LOH) and microsatellite instabilities (MSI), as well as extron expressionFour of 10 (40.0%) cases of primary GC showed absent or decreased expression of the FHIT protein as comparedThe findings in this study suggest that LOH and MSI of FHIT gene may induce aberrant extron expression
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Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 49-56 doi: 10.1007/s11684-009-0012-y

Abstract: The aim of this paper was to study the differential gene expression of giant cell tumor of bone (GCTBIII∶1 case; Campanacci I∶6 cases, II∶1 case, III∶1 case; Enneking Staging G T M : 5 cases, G T M : 2The gene expression disparity between the GCTB samples and normal bony callus was significantly different

Keywords： giant cell tumor of bone     gene     microarray     cDNA    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Here, based on 1741 patients with AML, we report a unique expression pattern associated with RUNX1This expression pattern was coordinated by target repression and promoter hypermethylation.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Heterologous expression of

Di Li,Swati Yewalkar,Xiaotao Bi,Sheldon Duff,Dusko Posarac,Heli Wang,Layne A. Woodfin,Jan-Hendrik Hehemann,Sheila C. Potter,Francis E. Nano

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0910-1

Abstract: was cultured in a photobioreactor to assess biomass yield, recombinant laminarinase activity, and CO2At a CO2 concentration of 5%, we obtained a maximum specific growth rate of 0.083 h , a biomass productivityAll parameters decreased as CO2 concentration increased from 5% to 10% and further to 15% CO2, exceptenzyme activity, which increased from 5% to 10% CO2.However, the mutant culture still grew at 15% CO2 concentration, as reflected by the biomass productivity

Keywords： PCC 7002     Thermotoga maritima     LamA gene     Endo-β-1     3-glucanase     CO2 fixation    

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Title Author Date Type Operation

Effects of podocin transfection on CD2AP distribution in HEK293 cells

SHA Yugen, HUANG Songming, ZHANG Aihua, ZHAO Fei, CHEN Ronghua

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium

Yan Chen,Wenyan Li,Wen Li,Renjie Chai,Huawei Li

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Journal Article

Effect of pEGFP-survivin on GBC-SD cell growth and chemotherapy sensitivity

Hanbin SHEN MD, Bin ZHANG MBA, Song ZHAO BM, Qichang ZHENG MD, Jianping GONG MD, Xiaotang CAI BM,

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Journal Article

Identification of genome regions and important variations associated with expression level of

Ye HOU,Lu JING,Yunxia ZHAO,Sheng WANG,An LIU,Shuhong ZHAO,Xinyun LI

Journal Article

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different

Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Journal Article

Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Heterologous expression of

Di Li,Swati Yewalkar,Xiaotao Bi,Sheldon Duff,Dusko Posarac,Heli Wang,Layne A. Woodfin,Jan-Hendrik Hehemann,Sheila C. Potter,Francis E. Nano

Journal Article